Chan-Zuckerberg Biohub Signs 10,666 Square Foot Lease At 100-104 Fifth Avenue Union Square
100 5th Avenue, 100–104 Fifth Avenue, Manhattan, Ny & 104 5th Avenue
Building Size
10,666 SF
Asset Type
Office
Closing
Aug 26, 2026
About this deal
AI
The property asset involved in this lease is located at 100-104 5th Avenue in the Union Square market. The asset type is classified as office space, encompassing a total square footage of 10,666. This lease pertains specifically to the entire ninth floor of the building.
Summary of transaction details:
- Property Type: Office
- Transaction Amount: Not disclosed
- Address: 100-104 5th Avenue
- Market: Union Square
- Landlord: Cyrus Sakhai - Sovereign Partners
- Tenant: Chan-Zuckerberg Biohub
The deal features Mark Zuckerberg and Priscilla Chan as the founders of the tenant, Chan-Zuckerberg Biohub, which is a biomedical research nonprofit. This lease marks a significant move for Biohub, as they secure a dedicated space for their operations in a prominent area of Union Square.
Players
New York Office Market Snapshot
Boundary boundary · Office · Lease transactions
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Purchase Price
Annual NOI
Loan Amount
Interest Rate (%)
Loan Term (yrs)
Down Payment (%)
Cap Rate
5.80%
Cash-on-Cash
-1.66%
Monthly Payment
$14,164
Annual Debt Svc
$169,964
Annual Cash Flow
$-11,334
DSCR
0.93